Research Publications and Findings

Inflammation & Immuno-Response

Janssen CW, Lowry CA, Mehl MR, et al. Whole-Body Hyperthermia for the Treatment of Major Depressive Disorder: A Randomized Clinical Trial. JAMA Psychiatry. Published online May 12, 2016. doi:10.1001/jamapsychiatry.2016.1031.

Raison, C.L. Inflammatory Depression: A Trifecta of Trouble. J Clin Psychiatry 75:6, June 2014: 663-4.

Raison, C.L., Miller, A.H., Rook, G.A.W., Begay, T. Role of Inflammation in Diseases of the Nervous System (Psychiatry). In: Zigmond, M.J., Coyle, J.T., Rowland, L.P. (Eds.) Neurobiology of Brain Disorders. Elsevier, 2013

Raison, C.L., Miller, A.H. The Role of Inflammation in Depression: Implications for Phenomenology, Pathophysiology and Treatment. In: Leonard, B., Halaris, A. (Eds.)  Modern Trends in Pharmacopsychiatry, Vol. 28, 2013; Karger Medical and Scientific Publishers, Basel, Switzerland

Raison CL, Miller AH (2013). Malaise, melancholia and madness: The evolutionary legacy of an inflammatory bias.  Brain Behav Immun. 2013 Jul;31:1-8.  PMCID: PMC3678371. Abstract

Mehta D, Raison CL, Woolwine BJ, Haroon E, Binder EB, Miller AH, Felger JC (2013). Transcriptional signatures related to glucose and lipid metabolism predict treatment response to the tumor necrosis factor antagonist infliximab in patients with treatment-resistant depression. Brain Behav Immun. Jul;31:205-15. PMCID: PMC3673885. Abstract

Felger JC, Li L, Marvar PJ, Woolwine BJ, Harrison DG, Raison CL, Miller AH (2013). Tyrosine metabolism during interferon-alpha administration: Association with fatigue and CSF dopamine concentrations.  Brain Behav Immun. Jul;31:153-60.  PMCID:PMC3578984. Abstract

Raison CL, Miller AH (2013).  The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D).  Mol Psychiatry. Jan;18(1):15-37.  PMCID:PMC3532038. Abstract.

Miller AH, Haroon E, Raison CL, Felger JC (2013). Cytokine targets in the brain: impact on neurotransmitters and neurocircuits. Depress Anxiety. Apr;30(4):297-306. Abstract

Raison CL, Rutherford RE, Woolwine BJ, Shuo C, Schettler P, Drake DF, Haroon E, Miller AH (2013). A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers.  JAMA Psychiatry. Jan;70(1):31-41. Abstract

Haroon E, Raison CL, Miller AH (2012). Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology. Jan;37(1):137-62. PMCID:PMC3238082. Abstract

Felger JC, Cole SW, Pace TW, Hu F, Woolwine BJ, Doho GH, Raison CL, Miller AH (2012).  Molecular signatures of peripheral blood mononuclear cells during chronic interferon-alpha treatment: relationship with depression and fatigue.  Psychol Med. Aug;42(8):1591-603. PMCID:PMC3433045. Abstract

McNutt MD, Liu S, Manatunga A, Royster EB, Raison CL, Woolwine BJ, Demetrashvili MF, Miller AH, Musselman DL (2012). Neurobehavioral effects of interferon-alpha in patients with hepatitis-C: symptom dimensions and responsiveness to paroxetine. Neuropsychopharmacology. May;37(6):1444-54. PMCID:PMC3327849. Abstract


Janssen CW, Lowry CA, Mehl MR, et al. Whole-Body Hyperthermia for the Treatment of Major Depressive Disorder: A Randomized Clinical Trial. JAMA Psychiatry. Published online May 12, 2016. doi:10.1001/jamapsychiatry.2016.1031

Shah, N. & Raison, C.L. Depression and the surgical patient. In: Lubin, M.F., Dodson, T.F., Winawer, N. (Eds.) Medical Management of the Surgical Patient: a Textbook of Perioperative Medicine, Cambridge University Press, 2013

 Shah, N. & Raison, C.L. Psychological and emotional reactions to illness and surgery. In: Lubin, M.F., Dodson, T.F., Winawer, N. (Eds.) Medical Management of the Surgical Patient: a Textbook of Perioperative Medicine, Cambridge University Press, 2013

Compassion & Mindfulness

Dodson-Lavelle, B., Ozawa-de Silva, B., Raison, C.L., and Negi, L.T. Healing Through Compassion: Cognitively-Based Compassion Training for Foster Care Youth. In:  Rozelle, D., Rome, D. (Eds.) Contemplative Methods in Trauma Treatment: Integrating Mindfulness and Other Approaches. Guilford Press, 2013

Mascaro JS, Rilling JK, Negi LT, Raison CL. Pre-existing brain function predicts subsequent practice of mindfulness and compassion meditation. Neuroimage. 2013 Apr 1;69:35-42. doi: 10.1016/j.neuroimage.2012.12.021. Epub 2012 Dec 22. Abstract

Raison, C.L., Mascaro, J.S., Pace, T.W. Research on the Endocrinology of Compassion. In: Compassion: From Theory to Training to Neuroscience. A Multimedia Book. Ed.: Singer, T.A., 2012

Desbordes G, Negi LT, Pace TW, Wallace BA, Raison CL, Schwartz EL. Effects of mindful-attention and compassion meditation training on amygdala response to emotional stimuli in an ordinary, non-meditative state. Front Hum Neurosci. 2012;6:292. doi: 10.3389/fnhum.2012.00292.Abstract.

Pace TW, Negi LT, Dodson-Lavelle B, Ozawa-de Silva B, Reddy SD, Cole SP, Danese A, Craighead LW, Raison CL. Engagement with Cognitively-Based Compassion Training is associated with reduced salivary C-reactive protein from before to after training in foster care program adolescents. Psychoneuroendocrinology. 2013 Feb;38(2):294-9. doi: 10.1016/j.psyneuen.2012.05.019. Epub 2012 Jul 3. Abstract.

Pace TW, Negi LT, Sivilli TI, Issa MJ, Cole SP, Adame DD, Raison CL. Innate immune, neuroendocrine and behavioral responses to psychosocial stress do not predict subsequent compassion meditation practice time. Psychoneuroendocrinology. 2010 Feb;35(2):310-5. doi: 10.1016/j.psyneuen.2009.06.008. Epub 2009 Jul 16. Abstract.

Pace TW, Negi LT, Adame DD, Cole SP, Sivilli TI, Brown TD, Issa MJ, Raison CL. Effect of compassion meditation on neuroendocrine, innate immune and behavioral responses to psychosocial stress. Psychoneuroendocrinology. 2009 Jan;34(1):87-98. doi: 10.1016/j.psyneuen.2008.08.011. Epub 2008 Oct 4. Abstract.


Rook, G.A.W., Lowry, C.A., Raison, C.L. Microbiota and the hygiene hypothesis of psychiatric disorders. In: Cryan, J.., Lyte, M. (Eds.) The Microbiota-Gut-Brain Axis in Health and Disease, Springer, 2013