2017

Kohler, C.A., Freitas, T.H., Maes, M., de Andrade, N.Q., Liu, C.S., Fernandes, B.S., Stubbs, B., Solmi, M., Veronese, N., Herrmann, N., Raison, C.L., Miller, B.J., Lanctot, K.L., Carvalho, A.F. Peripheral cytokine and chemokine alterations in depression: an up-dated meta-analysis of 82 studies. Acta Psychiatrica Scandinavia 2017; Epub - Full article.

 Kohler, C.A., Freitas, T.H., Stubbs, B., Maes, M., Solmi, M., Veronese, N., Andrede, N.Q., Morris, G., Fernandes, B.S., Brunoni, A.R., Hermann, N., Raison, C.L., Miller, B.J., Lactot, K.L., Carvalho, A. Peripheral alterations in cytokine and chemokine levels after antidepressant drug treatment: systematic review and meta-analysis. Molecular Neurobiology 2017; Epub. Full article.

2016

 Miller, A.H. & Raison, C.L. The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat Rev Immunol 2016; 16: 22-34. Full article.

Felger, J.C., Haroon, E., Woolwine, B.J., Raison, C.L., and Miller, A.H. 2016. Interferon-alpha-Induced Inflammation is Associated with Reduced Glucocorticoid Negative Feedback Sensitivity and Depression in Patients with Hepatitis C Virus. Physiology & Behavior 2016; 166:14-21. Full article.

Bollich, K.L., Doris, J.M., Vazire, S, Raison, C.L., Jackson, J.J. Mehl, M.R. Eavesdropping on Character: Assessing Everyday Moral Behaviors, Journal of Personality Research 2016; 61:15-21. Full article. 

Janssen, C.W. Lowry, C.A., Mehl, M.R., Allen, J.J.B., Kelly, K.L., Gartner, D.E., Medrano, A., Begay, T.K., Rentscher, K., White, J.J., Fridman, A., Roberts, L.J., Robbins, M.L., Hanusch, K. Cole, S.P., Raison, C.L. Whole body hyperthermia for the treatment of major depressive disorder: a randomized clinical trial. JAMA Psychiatry 2016; 73: 780-95. Full article. 

 Raison, C.L. The promise and limitations of anti-inflammatory agents for the treatment of major depressive disorder. Current Topics in Behavior Neurosciences 2016; epub. Full article. 

Pruimboom, L., Ruiz-Nunez, B., Raison, C.L., Muskiet, F.A.J. Influence of 10 days mimic of our ancient lifestyle on anthropometrics and parameters of metabolism and inflammation. Biomedical Research International 2016; 2016:6935123

Lowry, C.A., Smith, D.G., Siebler, P.H., Schmidt, D., Stamper, C.E., Hassell, J.E. Jr., Yamashita, P.S., Fox, H.H., Reber, S.O., Brenner, L.A., Hoisington, A.J., Postloche, T.T., Kinney, K.A., Marciani, D., Hernandex, M., Hemmings, S.M., Malan-Muller, S., Wrigth, K.P., Knight, R., Raison, C.L., Rook, G.A. The microbiota, immunoregulation, and mental health: implications for public health. Current Environtal Health Reports 2016; 3(3):270-86

Raison, C.L., Lowry, C.A., Janssen, C.W. Hyperthermia for major depression?—reply. JAMA Psychiatry 2016; 73(10):1096-1097

Reber, S.O., Siebler, P.H., Donner, N.C., Morton, J.T., Smith, D.G., Kopelman, J.M., Lowe, K.R., Wheeler, K.J., Fox, J.H., Hassell, J.E. Jr., Greenwood, B.N., Jansch, C., Lechner, A., Schmidt, D., Uschold-Schmidt, N., Füchsl, A.M., Langgartner, D., Walker, F.R., Hale, M.W., Lopez Perez, G., Van Treuren, W., González, A., Halweg-Edwards, A.L., Fleshner, M., Raison, C.L., Rook, G.A., Peddada, S.D., Knight, R., Lowry, C.A. Immunization with a heat-killed preparation of the environmental bacterium Mycobacterium vaccae promotes stress resilience in mice. Proc Natl Acad Sci U S A 2016;113(22):E3130-9.

Raison, C.L. & Miller, A.H. Pathogen-Host Defense in the Evolution of Depression: Insights into Epidemiology, Genetics, Bioregional Differences and Female Preponderance. Neuropsychopharmacology 2016; Epub

Reed, R.G., O’Connor, M-F. Pace, T.W.W., Raison, C.L., Butler, E.A. Immune Reactivity, Recovery and Diurnal Regulation in Response to Interpersonal Stress, Journal of Family Psychology; Epub

Mascaro, J.S., Kelley, S., Darcher, A., Negi, L.T., Worthman, C., Miller, A.H., Raison, C.L. Meditation buffers medical student compassion from the deleterious effects of depression. Journal of Positive Psychology 2016; Epub

2015

Raison, C.L., Hale, M.W., Williams, L.E., Wager, T.D., Lowry, C.A. Somatic influences on subjective well-being and affective disorders: the convergence of thermosensory and central serotonergic systems. Frontiers in Psychology, Section Cognition 2015; Jan 13; 5: 1580

Maletic V& Raison C. The integrated neurobiology of bipolar disorder. Frontiers in Psychiatry 2014;5:98. doi: 10.3389/fpsyt.2014.00098.

Miller, A.H. & Raison, C.L. Where the Rubber Meets the Road: Are Anti-inflammatory Therapies Viable Treatments for Psychiatric Disorders? JAMA Psychiatry 2015; 72: 527-8.

Mascaro, J.S., Darcher, A., Negi, L.T. Raison, C.L. The neural mediators of kindness-based meditation: a theoretical model. Frontiers in Psychology, Section Cognition 2015; 12: 109.

Pruimboom, L., Raison, C.L., Muskiet, F.A.J. Physical activity protects the human brain against metabolic stress induced by a postprandial and chronic inflammation. Behavioural Neurology 2015; 2015:569869

Dodds, S.E., Pace, T.W.W., Bell, M.L., Fiero, M., Negi, L.T., Raison, C.L, and Weihs, K. Feasibility of Cognitively-Based Compassion Training (CBCT) for Breast Cancer Survivors: A Randomized, Wait List Controlled Pilot Study. Supportive Care in Cancer 2015; 23: 3599-608.

2014

Rook, G.A.W., Raison, C.L., Lowry, C.A. Microbial “Old Friends,” immunoregulation and socio-economic status. Clinical and Experimental Immunology 2014; 177: 1-12.

Whisman, M.A., Li, A., Sbarra, D.A., Raison, C.L. Marital quality and diabetes: results from the health and retirement study, Health Psychology 2014; 33: 832-40.

Rook, G.A., Raison, C.L., Lowry, C.A. Microbiota, immunoregulatory old friends and psychiatric disorders. Advances in Experimental Medical Biology 2014; 817: 319-56.

Raison C.L. Inflammatory depression: a trifecta of trouble. Journal of Clinical Psychiatry 2014; 75: 663-4.

Rook, G.A., Lowry, C.A., Raison, C.L. Hygiene and other early childhood influences on the subsequent function of the immune system. Brain Research 2014; S0006-8993(14)00481-8.

Maletic V & Raison, C.L. Integrated neurobiology of bipolar disorder. Frontiers in Psychiatry 2014; 5:98

Weinberger, J.F., Raison, C.L., Montague, A.K., Woolwine, B.J., Felger, J.C., Haroon, E. Miller, A.H. Inhibition of Tumor Necrosis Factor Improves Sleep Continuity in Patients with Treatment Resistant Depression and High Inflammation. Brain, Behavior and Immunity 2014: 47: 193-200.

2013

Rook, G.A., Raison, C.L., Lowry, C.A. Childhood microbial experience, immunoregulation, inflammation and adult susceptibility to psychosocial stressors and depression in rich and poor countries. Evolutionary Medicine and Public Health 2013; 12: 14-17.

 Mascaro, J.S., Rilling, J.K., Negi, L.T., Raison, C.L. Pre-existing brain function predicts subsequent practice of mindfulness and compassion meditation. Neuroimage 2013; 69:35-42.

Berg, J.M., Lilienfeld, S.O., Reddy, D., Latzman, R.D., Roosem A., Craighead, L.W., Pace, T.W., Raison, C.L. The Inventory of Callous and Unemotional Traits: A Construct-Validational Analysis in an At-Risk Sample. Assessment 2013; 20: 532-44.

Miller, A.H., Haroon, E., Raison, C.L., Felger, J.C. Cytokine Targets in the Brain: Impact on Neurotransmitters and Neurocircuits. Depression & Anxiety 2013; 30::297-306.

Rook, G.A.W., Lowry, C.A., Raison, C.L. Microbial “Old Friends,” immunoregulation and stress resilience. Evolution, Medicine and Public Health 2013; 13: 46-64.

Hanusch, K., Janssen, C.H., Billheimer, D, Jenkins, I., Spurgeon, E., Lowry, C.A., Raison, C.L. Whole Body Hyperthermia (WBH) for the Treatment of Major Depression: Associations with Thermoregulatory Cooling. American Journal of Psychiatry 2013; 170: 802-4.

2012

Haroon, E., Raison, C.L., Miller, A.H. Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior. Neuropsychopharmacology 2012; 37(1): 137-62.

Raison, C.L. & Miller, A.H. Is Depression an Inflammatory Disorder? Current Psychiatry Reports 2011; 13(6): 467-75.

Felger, J.C., Cole, S.W., Pace, T.W.W., Hu, F., Woolwine, B.J., Doho, G.H., Raison, C.L., Miller, A.H. Molecular Signatures of Peripheral Blood Mononuclear Cells during Chronic Interferon-alpha Treatment: Relationship with Depression and Fatigue. Psychological Medicine 2012; 42: 1591-603.

Raison, C.L. & Miller, A.H. The Evolutionary Significance of Depression in Pathogen Host Defense (PATHOS-D). Molecular Psychiatry 2013; 18::15-37.

Reddy, S.D., Negi, L.T., Dodson-Lavelle, B., Ozawa de-Silva, B., Pace, T.W., Cole, S.P., Raison, C.L., Craighead, L.W. Cognitively-Based Compassion Training: a promising prevention strategy for at-risk adolescents. Journal of Child and Family Studies 2012; Epub.

Rook, G.A.W., Raison, C.L., Lowry, C.A. Can we vaccinate against depression. Drug Discovery Today 2012; 17: 451-8.

Johnson, T.V., Abbasi, A., Ehrich, S.S., Kleris, R.S., Owen-Smith, A., Raison, C.L. Master, V.A. IPSS quality of life question: a possible indicator of depression among patients with lower urinary tract symptoms. Canadian Journal of Urology 2012; 19: 6100-4.

McNutt, M.D., Liu S., Manatunga, A., Royster, E.B., Raison, C.L., Woolwine, B.J., Demetrashvili, M.F., Miller, A.H., Musselman, D.L. Neurobehavioral Effects of Interferon-α in Patients with Hepatitis-C: Symptom Dimensions and Responsiveness to Paroxetine. Neuropsychopharmacology 2012; 37:1444-54.

Pace, T.W., Negi, L.T., Dodson-Lavelle, B., Ozawa-de Silva, B. Reddy, S.D., Cole, S.P., Danes, A., Craighead, L.W., Raison, C.L. Engagement with Cognitively-Based Compassion Training is associated with reduced salivary C-reactive protein from before to after training in foster care program adolescents. Psychoneuroendocrinology 2012; 38: 294-9.

Raison, C.L., Haroon, E., Woolwine, B.J., Shuo, C., Haber, M. Rutherford, R., Miller, A.H. A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. Archives of General Psychiatry 2012; 70: 31-41.

Mascaro, J.S., Rilling, J.K., Negi, L.T., Raison, C.L. Compassion meditation enhances empathic accuracy and related neural activity. Social Cognitive and Affective Neuroscience 2012; 8: 48-55.

Desbordes, G., Negi, L.T., Pace, T.W., Wallace, B.A., Raison, C.L., Schwartz, E.L. Effects of mindful-attention and compassion meditation training on amygdala response to emotional stimuli in an ordinary, non-meditative state. Frontiers in Neuroscience 2012; 6: 292.

Hale, M.W., Raison, C.L., Lowry, C.A. Integrative physiology of depression and antidepressant drug action: implications for serotonergic mechanisms of action and novel therapeutic strategies for treatment of depression. Pharmacology & Therapeutics 2012; 137:108-18.

Felger, J.C., Li, L., Marvar, P.J., Woolwine, B.J., Harrison, D.G., Raison, C.L., and Miller, A.H.. Tyrosine Metabolism During Interferon-alpha Administration: Association with Fatigue and CSF Dopamine Concentrations. Brain, Behavior, and Immunity 2012; 31:153-60.

2011

Johnson, T.V., Abbasi, A., Ehrlich, S.S., Kleris, S.S., Chirumamilla, S.L., Schoenberg, E.D., Owen-Smith, A., Raison, C.L., Master, V.A. Nocturia associated with depressive symptoms. Urology 2011. 77(1):183-6.

Jain, R., Jain, S., Raison, C.L., Maletic, V. Painful Diabetic Neuropathy is more than Pain Alone: Examining the Role of Anxiety and Depression as Mediators and Complicators. Current Diabetes Reports 2011; 11(4): 275-84.

Felger, J.C., Alagbe, T., Pace, T.W.W., Woolwine, B.J., Raison, C.L., and Miller AH. Early activation of p38 mitogen activated protein kinase is associated with interferon-alpha-induced depression.  Brain, Behavior and Immunity 2011; 25(6): 1094-8.

Haroon, E., Raison, C.L., Miller, A.H. Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior. Neuropsychopharmacology 2012; 37(1): 137-62.

Raison, C.L. & Miller, A.H. Is Depression an Inflammatory Disorder? Current Psychiatry Reports 2011; 13(6): 467-75.

2010

Raison, C.L., Woolwine, B.J., Borisov, A.S., Cowles, Alagbe, O., M., Vogt, G., Miller, A.H. Effects of Interferon-alpha on diurnal hypothalamic-pituitary-adrenal axis activity and behavior in patients with hepatitis C. Molecular Psychiatry 2010; 15: 535–547.

Pace, T.W.W., Negi, L.T., Sivilli, T.S., Issa, M.J., Cole, S.P., Adame, D.D., Raison, C.L. Innate Immune, Neuroendocrine and Behavioral Responses to Psychosocial Stress do not predict Subsequent Compassion Meditation Practice Time. Psychoneuroendocrinology 2010; 35: 310-15.

Raison, C.L., Dantzer, R. Kelley, K.W., Lawson, M.A., Woolwine, B.J., Vogt, G., Spivey, J.R., Saito, K., Miller, A.H. CSF Concentrations of Brain Tryptophan and Kynurenines during Immune Stimulation with IFN-alpha: Relationship to CNS Immune Responses and Depression. Molecular Psychiatry 2010;15: 393-403.

Johnson, T.V., Abbasi, A., Ehrlich, S.S., Kleris, S.S., Chirumamilla, S.L., Schoenberg, E.D., Owen-Smith, A., Raison, C.L., Master, V.A/ (2010) Major depression drives severity of American Urological Association Symptom Score. Urology 2010. 76(6):1317-1320.

Raison, C.L., Rye, D.B., Woolwine, B.J., Vogt, G., Bautista, B.M., Spivey, J., Miller, A.H. Chronic Interferon-Alpha Administration Disrupts Sleep Continuity and Depth in Patients with Hepatitis C: Association with Fatigue, Motor Slowing and Increased Evening Cortisol. Biological Psychiatry 2010;68(10): 942-9.

Johnson, T.V., Abbasi, A., Ehrlich, S.S., Kleris, R.S., Chirumamilla, S.L., Schoenberg, E.D., Owen-Smith, A., Raison, C.L., Master, V.A. Major depression drives severity of American urological association symptom index. Urology 2010;76(6): 1317-20.

Raison, C.L., Lowry, C.A., Rook, G.A.W. Inflammation, Sanitation and Consternation: Loss of Contact with Co-Evolved, Tolerogenic Micro-Organisms and the Pathophysiology and Treatment of Major Depression, Archives of General Psychiatry 2010 67(12):1211-24.

2009

Raison, C.L., Borisov, A.S., Woolwine, B.J., Vogt, G.J., Massung, B. Miller, A.H. Activation of CNS inflammatory pathways by interferon-alpha: relationship to monoamines and depression. Biological Psychiatry 2009; 65(4):296-303.

Pace, T.W.W., Negi, L.T., Adame, D, Cole, S.P., Sivilli, T.S., Brown, T., Issa, M., Raison, C.L. Effect of compassion meditation on neuroendocrine, innate immune and behavioral responses to psychosocial stress. Psychoneuroendocrinology 2009; 34(1):87-98.

Raison, C.L. Lin, J.S., Reeves, W.C. Association of peripheral inflammatory markers with chronic fatigue in a population-based sample. Brain, Behavior and Immunity 2009; 23(3):327-37.

Nater, U.M., Lin, J.M., Maloney, E.H., Jones, J.F., Tian, H., Boneva, R.S., Raison, C.L., Reeves, W.C. Psychiatric Comorbidity in Persons with Chronic Fatigue Syndrome Identified from the Georgia Population. Psychosomatic Medicine 2009, Epub.

Miller, A.H., Maletic, V., Raison, C.L. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biological Psychiatry 2009; 65(9):732-41.

Maletic, V. & Raison, C.L. At the Crossroads of Mind and Body: Focus on the Neurobiology of Depression, Fibromyalgia and Neuropathic Pain. Frontiers in Bioscience 2009. 14: 5291-5338.

Nater, U.M., Lin, J.M., Maloney, E.H., Jones, J.F., Tian, H., Boneva, R.S., Raison, C.L., Reeves, W.C. Criteria for chronic fatigue syndrome and co-morbid psychiatric conditions—Response to Kindlon. Psychosomatic Medicine 2009. 71(5):557-65.

2008

Majer, M., Welberg, L.A., Capuron, L., Pagnoni, G., Raison, C.L., Miller, A.H. IFN-alpha-induced motor slowing is associated with increased depression and fatigue in patients with chronic hepatitis C.  Brain Behavior and Immunity 2008; 22(6): 870-80.

Evans, D., Buxton, D.C., Borisov, A.S., Manatunga, A.K., Ngodup, D., Raison, C.L. (corresponding author). Shattered Shangri-la: differences in depressive and anxiety symptoms in students born in Tibet compared to Tibetan students born in exile. Social Psychiatry and Psychiatric Epidemiology 2008; 43(6): 429-36.

2007

Silverman, M.N., Macdougall, M.G., Raison, C.L., Miller, A.H. Endogenous glucocorticoids protect against TNF-alpha-induced increases in anxiety-like behavior in virally-infected mice. Molecular Psychiatry 2007; 12(4): 408-17.

Raison, C.L., Woolwine, B.J., Binongo, J., Demitrashvili, M.F., Borisov, A.F., Weinreib, R., Staab, J.P., Zajecka, J.M., Bruno, C.J., Henderson, M.A., Reinus, J.F., Evans, D.L., Asnis, G.M., Miller, A.H. Paroxetine for Prevention of Depressive Symptoms Induced by Interferon-alpha plus Ribavirin for Hepatitis C. Alimentary Pharmacology & Therapeutics 2007; 25(10): 1163-74.

2006

Raison, C.L. The effects of hepatitis C and its treatment on mental health. Focus: A Guide to AIDS Research and Counseling 2006. 21(5): 5-6.

Raison, C.L., Afdhal, N.H. Neuropsychiatric side effects associated with interferon-alfa plus ribavirin therapy: Recognition and risk factors. In: UpToDate, Rose, B.D. (Ed), UpToDate, Waltham, MA, 2006.

Raison, C.L., Afdhal, N.H. Neuropsychiatric side effects associated with interferon-alfa plus ribavirin therapy: Treatment and prevention. In: UpToDate, Rose, B.D. (Ed), UpToDate, Waltham, MA, 2006.

2005

Raison, C.L., Broadwell, S.D., Borisov, A.S., Manatunga, A.K., Woolwine, B.J., Jacobson, I.M., Nemeroff, C.B., Miller, A.H. Depressive symptoms and viral clearance in patients receiving IFN-alpha and Ribavirin for Hepatitis C. Brain, Behavior and Immunity 2005; 19: 23-27.

Raison, C.L., , Borisov, Broadwell, S.D., A.S., Manatunga, A.K., Woolwine, B.J., Jacobson, I.M., Nemeroff, C.B., Miller, A.H. Depression during pegylated IFN-alpha plus ribavirin therapy: prevalence and prediction. Journal of Clinical Psychiatry 2005;66;1:41-48.

Raison, C.L., Demetrashvili, M., Capuron, L., Miller, A.H. Neuropsychiatric Side Effects of Interferon-alpha: Recognition and Management. CNS Drugs, 2005; 19(2): 1-19.

Raison, C.L., Demetrashvili, M., Capuron L., Miller A.H. The authors' reply.  CNS Drugs 2005. 19(8):721-2.

Miller, A.H., Capuron, L., Raison, C.L. Immunologic influences on emotion regulation. Clinical Neuroscience Research 2005; 4(5-6): 235-333.

Yoshida, K., Alagbe, O., Wan, X., Woolwine, B., Thornbury, M., Raison, C.L., Miller, A.H. Promotor polymorphisms of the interferon-alpha receptor gene and development of interferon-induced depressive symptoms in patients with chronic hepatitis C. Neuropsychobiology 2005; 52(2):55-61.

Raison, C,L., Capuron L., Miller A.H. Depressive symptoms and viral clearance: In response. Brain, Behavior, and Immunity 2005; 19(4):273-4.

2004

Asnis, G.M., De La Garza II, R, Miller, A.H., Raison, C.L., Ribavirin May Be an Important Factor in IFN-Induced Neuropsychiatric Effects.  Journal of Clinical Psychiatry 2004; 65(4): 581.

2003

Capuron, L., Raison, C.L., Lawson, D.H., Musselman, D.L., Su, C., Nemeroff, C.B., Miller, A.H. An exaggerated HPA axis response to initial injection of interferon-alpha is associated with depression during interferon-alpha therapy. American Journal of Psychiatry 2003; 160(7): 1342-1345.

Raison, C.L. & Miller, A.H. When Not Enough Is Too Much: The Role of Insufficient Glucocorticoid Signaling in the Pathophysiology of Stress-Related Disorders. American Journal of Psychiatry. 2003;160: 1554-1565.

 Raison, C.L. & Miller, A.H. Depression in Cancer:  New Developments Regarding Diagnosis and Treatment. Biological Psychiatry, 2003; 54: 283-294.

2002

Raison, C.L., Marcin, M., Miller, A.H. Antidepressant treatment of cytokine-induced depression.. Acta Neuropsychiatrica. 2002: 4.

2001

Raison, C.L., Miller, A.H. The Neuroimmunology of Stress and Depression. Seminars in Clinical Neuropsychiatry. 2001. 6; 4: 277-294.

1998

Raison C.L., Klein H.M., Steckler M..  The Moon and Madness reconsidered. 1998. Journal of Affective Disorders 53; 1: 99-106.

1997

Raison CL, Klein HM. Psychotic mania associated with fenfluramine and phentermine use (letter). American Journal of Psychiatry 1997; 154: 711.

1994

Raison CL, Guze BH, Kissell RL.  Successful treatment of clozapine-induced agranulocytosis with granulocyte colony-stimulating factor (letter).  Journal of Clinical Psychopharmacology 1994; 14:285-86.